Tag Archives: n of 1
Here at QS Labs we take great pride in supporting a worldwide network of meetup groups. From Bucharest to the Bay Area, we have over 100 groups meeting to discuss self-tracking, share experiences, and learn from each other.
We wanted to highlight a new group, based in southern Oregon, that is using self-tracking to expand and influence medical knowledge within the healthcare system. Dr. Dawn Lemanne, a board certified and practicing oncologist, has started the new Individual Metabolic Research Group (iMeRG) to develop, test, and explore inexpensive way to prevent and treat chronic diseases related to lifestyle, through rigorous N of 1 research methods.
Currently the iMERG is a composed of physicians and other health care professionals frustrated by the rising rates of lifestyle driven chronic disease, and the failure of the large randomized controlled trial (RCT) to provide effective interventions. Inspired by QS, they are working together to develop and use rigorous N of 1 research designs, while using themselves (not their patients) as subjects. Members propose projects, and together they figure out how to do it. QS devices and philosophies play a major role in the data collection and analysis methods being talked about at the group. Current proposals have included:
- How best to measure the effect of combining intermittent fasting and exercise on blood ketone levels and inflammatory markers in a sedentary postmenopausal woman
- The clinical manifestations of Familial Mediterranean Fever gene heterozygosity.
Join the group! If you hold a license to practice a health profession (MD, DO, DDS, DMD, RN, NP, PA, DC, ND, LAc, etc.), you’re interested in N of 1 research design and methods, and you’d like to be involved, please contact Dawn. All individuals are welcome, regardless of geographic location. If you’re in the southern Oregon area you can join their meetup group on February 28th. We’ll be posting updates from the group as their research progresses.
“Personal experimentation is simply tracking, on a schedule.”
Ian Eslick is a scientist, researcher, and self-tracker. His unique history has led him down a path towards understanding what it means to understand yourself and your health in and outside the world of healthcare. Ian’s health history helped push him down this path. Since being diagnosed with psoriasis he’s been confronted with the difficult task of figuring out triggers, effects, and treatments as his symptoms changed over time. Ian, began to explore self-tracking by mentally noting what was going on in his life and his symptom severity. You would think that this “in my own head” tracking methodology would limit analytical capabilities, but it helped Ian create mental models that informed more consistent and rigorous tracking methods, as well as influenced his future research.
In this talk below Ian describes that research, both personal and community-based, that explored the concept of helping people learn how to create and engage with personal experimentation.
“What I came to in conclusion after all of this is that N of 1 is overkill for QS. It’s unnecessary level of rigor. Ninety-five percent confidence intervals are about scientific causal proof, but what I want to know is am I making a better decision. Is data improving my decision in some measurable way? Not is it a perfect decision or do I have proof. So we want to value personal significance over statistical significance. Statistical significance says that if I run this trial twenty more times I’m likely to get the same result, but what I want to know is should I keep doing this and in QS we’re never going to stop keep experimenting, in a way, because our life keeps going.”